Combination of intramuscular transplantation of autologous mononuclear bone marrow cells with sympathectomy (L2, 3) in patients with peripheral arterial disease(PAD)

Background: In most patients with severe, chronic extremity ischemic diseases, intervention or surgical treatment is often not suitable. Combination of intramuscular transplantation of autologous monocular bone marrow cells (AMBMCs) and sympathectomy (L2, 3) has been proved therapeutically beneficial. Methods: We studied 170 patients (combined group 80, control group 90) with extremity ischemia (TAO, ASO FontaineII,III, IV) between January 2013 and September 2019. Results: In contrast to pre-operation, the walking distance of patients increased significantly (from 61.34 +/- 52.23 m to 156.0 +/- 32.4 m, p < 0.01), and the ankle-brachial index (ABI) remarkably improved (from 0.28 +/- 0.13 to 0.59 +/- 0.23, p < 0.05). Conclusion: Combined therapy is feasible and effective for patients with peripheral arterial disease (PAD). (c) 2021 Published by Elsevier Ltd on behalf of Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland.