Genetic polymorphisms associated with polycystic ovary syndrome among Iranian women

被引:7
作者
Jamshidi, Mohammad [1 ]
Pour, Somayeh Mohammadi [2 ]
Bahadoram, Mohammad [3 ]
Mahmoudian-Sani, Mohammad-Reza [3 ]
Boroujeni, Ali Saeedi [4 ,5 ]
机构
[1] Lorestan Univ Med Sci, Sch Allied Med, Dept Lab Sci, Khorramabad, Iran
[2] Univ Med Sci, Sch Med Lorestan, Dept Obstet & Gynecol, Khorramabad, Iran
[3] Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst, Thalassemia & Hemoglobinopathy Res Ctr, Ahvaz, Iran
[4] Ahvaz Jundishapur Univ Med Sci, Dept Immunol, Fac Med, Ahvaz, Iran
[5] Univ Sci Educ & Res Network, ImmunologyToday, Tehran, Iran
关键词
biomarker; inflammation; insulin resistance; metabolism; polycystic ovarian syndrome; single nucleotide polymorphisms; INSULIN-RECEPTOR GENE; PLASMINOGEN-ACTIVATOR INHIBITOR-1; SINGLE-NUCLEOTIDE-POLYMORPHISM; TYROSINE-KINASE-DOMAIN; ADIPONECTIN GENE; SYNDROME RISK; CIRCULATING ADIPONECTIN; PRO12ALA POLYMORPHISM; 4G/5G POLYMORPHISM; INDUCED APOPTOSIS;
D O I
10.1002/ijgo.13534
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Polycystic ovary syndrome (PCOS) involves abnormalities in ovarian, reproductive, and metabolic systems. Genetic polymorphisms associated with individual differences and variations might be related to complex disorders with unknown causes, including PCOS. Several leading genetic markers with known cellular functions have been identified among Iranian women presenting with PCOS. In particular, the existing evidence shows a significant relationship between PCOS and the following genetic polymorphisms: rs2275913 (interleukin-17A), rs9927163 (interleukin-32), Pro12Ala (peroxisome proliferator-activated receptor-gamma), rs17173608 (chemerin), rs2236242 (vaspin), ApaI (vitamin D receptor), and rs7895833 (sirtuin 1). In addition, a higher risk of PCOS is associated with the rs2910164 (microRNA 146a), rs2241766 (adiponectin), -34 T/C (cytochrome 17), and rs1800682 (Fas) polymorphisms. Furthermore, protective effects against PCOS have been reported for the A4223C polymorphism of adenosine deaminase 1. Overall, the available data indicate that Iranian women with PCOS have a higher prevalence of polymorphisms in inflammation- and metabolism-related genes, but not in insulin-related genes. More extensive studies are needed to identify the ethnicity-related genetic associations in PCOS. Among Iranian women, polycystic ovary syndrome is significantly associated with inflammation- and metabolism-related gene polymorphisms, but not with polymorphisms of insulin-related genes.
引用
收藏
页码:33 / 44
页数:12
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