Using Precision Medicine with a Neurodevelopmental Perspective to Study Inflammation and Depression

被引：3

作者：

Levitan, Robert D. ^{[1
,2
,3
,4
]}

Zhang, Cindy X. W. ^{[4
]}

Knight, Julia A. ^{[5
,6
]}

Hung, Rayjean ^{[5
,6
]}

Lye, Jennifer ^{[5
]}

Murphy, Kellie ^{[5
,7
]}

Atkinson, Leslie ^{[8
]}

Bocking, Alan ^{[5
,7
]}

Lye, Stephen ^{[4
,5
,7
]}

Matthews, Stephen G. ^{[4
,5
,7
]}

机构：

[1] Ctr Addict & Mental Hlth, Mood & Anxiety Disorders Program, 100 Stokes St, Toronto, ON M6J 1H4, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[5] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[7] Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON, Canada

[8] Ryerson Univ, Dept Psychol, Toronto, ON, Canada

来源：

CURRENT PSYCHIATRY REPORTS | 2020年 / 22卷 / 12期

关键词：

Inflammation; Depression; Precision medicine; Neurodevelopment; Developmental window; sex differences; C-REACTIVE PROTEIN; HS-CRP; SYMPTOMS; MARKERS; CONNECTIVITY; MECHANISMS; PREGNANCY; ANHEDONIA; BEHAVIOR; DEFINE;

D O I：

10.1007/s11920-020-01206-8

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Purpose of Review To consider various precision medicine approaches to further elucidate the relationship between inflammation and depression and to illustrate how a neurodevelopmental perspective can help in this regard. Recent Findings Inflammation associates most strongly with phenotypes of depression that reflect illness behavior and/or metabolic dysfunction and obesity. A separate body of research has shown that maternal inflammation during pregnancy can alter brain circuitry important for mood regulation and/or reward in the developing fetus. Our research group is finding that maternal CRP levels differentially predict positive and negative affect in children assessed at age 4 years, depending on the timing of plasma sampling during pregnancy and the sex of the child. Recent authors have stressed the need to use a variety of precision medicine approaches to refine our understanding of inflammation-depression links. Adding a neurodevelopmental perspective may help to address some of the methodological challenges in this active area of study.

引用

页数：6

共 42 条

[1] Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children [J].