Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.

被引：33

作者：

Yang, Ming-Hua ^{[1
]}

Li, Tian-Xiao ^{[1
]}

Wang, Ying ^{[1
]}

Liu, Rui-Huan ^{[1
]}

Luo, Jun ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

FITOTERAPIA | 2017年 / 116卷

基金：

中国国家自然科学基金;

关键词：

Penicillium sp; Phenolic metabolites; Dichlorine; Antimicrobial; ABSOLUTE-CONFIGURATION; A-C; POLYKETIDES;

D O I：

10.1016/j.fitote.2016.11.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh-2(OCOCF3)(4)]-induced electronic circular dichroism (ECD) experiments. Compounds 2-4 and 6 structurally involved acyclic 1.3-diols, the uneasy configuration determinations of which were well carried out by double-derivation NMR methods. Compounds 1-10 were evaluated for their antibacterial and antifungal activities against five strains of human pathogenic microorganisms. Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6 mu g/mL, respectively. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：72 / 76

页数：5

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