THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Nuclear hormone receptors

被引:114
作者
Alexander, Stephen P. H. [1 ]
Cidlowski, John A. [2 ]
Kelly, Eamonn [3 ]
Marrion, Neil [3 ]
Peters, John A. [4 ]
Benson, Helen E. [5 ]
Faccenda, Elena [5 ]
Pawson, Adam J. [5 ]
Sharman, Joanna L. [5 ]
Southan, Christopher [5 ]
Davies, Jamie A. [5 ]
Aldrich, R.
Attali, B.
Back, M.
Barnes, N. M.
Bathgate, R.
Beart, P. M.
Becirovic, E.
Biel, M.
Birdsall, N. J.
Boison, D.
Brauner-Osborne, H.
Broeer, S.
Bryant, C.
Burnstock, G.
Burris, T.
Cain, D.
Calo, G.
Chan, S. L.
Chandy, K. G.
Chiang, N.
Christakos, S.
Christopoulos, A.
Chun, J. J.
Chung, J. -J.
Clapham, D. E.
Connor, M. A.
Coons, L.
Cox, H. M.
Dautzenberg, F. M.
Dent, G.
Douglas, S. D.
Dubocovich, M. L.
Edwards, D. P.
Farndale, R.
Fong, T. M.
Forrest, D.
Fowler, C. J.
Fuller, P.
Gainetdinov, R. R.
机构
[1] Univ Nottingham, Sch Med, Sch Biomed Sci, Nottingham NG7 2UH, England
[2] NIEHS, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
[3] Univ Bristol, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England
[4] Univ Dundee, Med Educ Inst, Ninewells Hosp & Med Sch, Neurosci Div, Dundee DD1 9SY, Scotland
[5] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland
关键词
UNION-OF-PHARMACOLOGY; RETINOID-X-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTORS; LIGAND-BINDING DOMAIN; DIGLYCIDYL ETHER BADGE; PPAR-GAMMA AGONISTS; ST JOHNS WORT; REV-ERB-ALPHA; BIOLOGICAL-ACTIVITY;
D O I
10.1111/bph.13352
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13352/full. Nuclear hormone receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.
引用
收藏
页码:5956 / 5978
页数:23
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