Liquid Nitrogen Cryotherapy for Conjunctival Amyloidosis

Conjunctival amyloidosis is a rare disease, the etiology of which is not completely understood. Four patients with primary localized conjunctival amyloidosis without systemic involvement or antecedent ocular disease underwent liquid nitrogen cryotherapy either after surgical biopsy (3 patients) or alone. Two patients had posttreatment recurrence of conjunctival amyloidosis and received 2 rounds of cryotherapy per affected eye (per patient). All the patients were satisfied with their surgical results, and conjunctival amyloidosis was eradicated in all 4 after cryotherapy. Although surgical debulking is the usual treatment for this disease, liquid nitrogen cryotherapy to the ocular surface seems to be a safe and effective adjunct or alternative treatment. Arch Ophthalmol. 2009;127(5):645-648