Bone Involvement and Osteoporosis in Mastocytosis

被引：63

作者：

Rossini, Maurizio ^{[1
]}

Zanotti, Roberta ^{[1
]}

Viapiana, Ombretta ^{[1
]}

Tripi, Gaia ^{[1
]}

Orsolini, Giovanni ^{[1
]}

Idolazzi, Luca ^{[1
]}

Bonadonna, Patrizia ^{[1
]}

Schena, Donatella ^{[1
]}

Escribano, Luis ^{[1
]}

Adami, Silvano ^{[1
]}

Gatti, Davide ^{[1
]}

机构：

[1] Univ Verona, Policlin Borgo Roma, I-37134 Verona, Italy

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2014年 / 34卷 / 02期

关键词：

Mastocytosis; Osteoporosis; Osteosclerosis; Fracture; Bone mineral density; Bone turnover markers; MAST-CELL DISEASE; SYSTEMIC MASTOCYTOSIS; MARROW MASTOCYTOSIS; RETROSPECTIVE ANALYSIS; HISTAMINE-RECEPTORS; INTERFERON-ALPHA; INDOLENT; OSTEOPENIA; FRACTURE; PAMIDRONATE;

D O I：

10.1016/j.iac.2014.01.011

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Bone involvement is frequent in patients with systemic mastocytosis. Osteoporosis is the most prevalent bone manifestation, but diffuse osteosclerosis or focal osteolytic or osteosclerotic lesions are not infrequent. The risk of osteoporotic fractures is high, especially at the spine and In men. Routine measurements of bone mineral density and vertebral, morphometry are warranted. The bone turnover markers indicate the involvement of complex bone metabolism in mastocytosis-related manifestations.. Bisphosphonates represent the first-line treatment for osteoporosis-related mastocytosis.

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页码：383 / +

页数：15

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