Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume

被引：16

作者：

Caldwell, Jessica Z. K. ^{[1
]}

Berg, Jody-Lynn ^{[1
]}

Shan, Guogen ^{[2
]}

Cummings, Jeffrey L. ^{[1
]}

Banks, Sarah J. ^{[1
]}

机构：

[1] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, 888 W Bonneville Ave, Las Vegas, NV 89106 USA

[2] Univ Nevada, Sch Community Hlth Sci, Las Vegas, NV 89154 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 64卷 / 01期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Alzheimer's disease; amyloid; magnetic resonance imaging; memory; mild cognitive impairment; positron emission tomography; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; VERBAL MEMORY; GEOMETRICALLY ACCURATE; FEMALE ADVANTAGE; SEGMENTATION; MRI; NEURODEGENERATION; DEMENTIA; STATES;

D O I：

10.3233/JAD-180028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined moderation effects of sex and diagnosis on the effect of positive florbetapir positron emission tomography (PET) amyloid-beta (A beta) scan (A+) on hippocampus subfield volumes in 526 normal control (NC) and early mild cognitive impairment (eMCI) participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression moderation models showed that women-but not men-with NC designation did not show reduced subiculum volumes despite A+. At the eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for the effects of age, cognition at screening, education, and APOE4 carrier status. These findings suggest that women with A+ have early neural resistance to Alzheimer's disease-related amyloid burden.

引用

页码：79 / 89

页数：11

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