Heterogeneity of Head and Neck Squamous Cell Carcinoma Stem Cells

被引：10

作者：

Qian, Xu ^{[1
,2
,3
,4
,5
]}

Nie, Xiaobo ^{[6
]}

Wollenberg, Barbara ^{[7
]}

Sudhoff, Holger ^{[8
]}

Kaufmann, Andreas M. ^{[2
,3
,4
,9
]}

Albers, Andreas E. ^{[1
,2
,3
,4
]}

机构：

[1] Charite Univ Med Berlin, Dept Otorhinolaryngol Head & Neck Surg, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] Zhejiang Canc Hosp, Dept Lab Med, Div Mol Diagnost, Hangzhou, Zhejiang, Peoples R China

[6] Henan Univ, Sch Basic Med Sci, Key Lab Receptors Mediated Gene Regulat & Drug Di, Kaifeng, Peoples R China

[7] Univ Hosp Schleswig Holstein, Clin Otorhinolaryngol Head & Neck Surg, Campus Lubeck, Lubeck, Germany

[8] Klinikum Bielefeld, Dept Otorhinolaryngol Head & Neck Surg, Bielefeld, Germany

[9] Charite Univ Med Berlin, Clin Gynecol, Berlin, Germany

来源：

STEM CELLS HETEROGENEITY IN CANCER | 2019年 / 1139卷

关键词：

Head and neck squamous cell carcinoma (HNSCC); Epidermal growth factor receptor (EGFR); Cancer stem cell (CSC); Immunotherapy; Epithelial-to-mesenchymal transition (EMT); Mesenchymal-to-epithelial transition (MET); Aldehyde dehydrogenase I; Immune response; Immune evasion; PD-1; PD-L1; Tumor microenvironment; CSC-directed therapeutic; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM(-LIKE) CELLS; ALDEHYDE DEHYDROGENASE 1; TUMOR-INITIATING CELLS; PUTATIVE MARKER; SELF-RENEWAL; ORAL-CANCER; EXPRESSION; HYPOXIA; PROMOTES;

D O I：

10.1007/978-3-030-14366-4_2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

引用

页码：23 / 40

页数：18

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