The role of the transcription factor Ets1 in carcinoma

被引：163

作者：

Dittmer, Juergen ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Klin Gynakol, D-06120 Halle, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2015年 / 35卷

关键词：

Ets1; Drug resistance; EMT; Triple-negative breast cancer; HEPATOCYTE GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ALPHA-B-CRYSTALLIN; MESSENGER-RNA EXPRESSION; CHEMOKINE RECEPTOR CXCR4; BREAST-CANCER CELLS; PML NUCLEAR-BODIES; DNA-BINDING; GENE-EXPRESSION; UP-REGULATION;

D O I：

10.1016/j.semcancer.2015.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ets1 belongs to the large family of the ETS domain family of transcription factors and is involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor survival. In breast cancer, Ets1 is primarily expressed in the triple-negative subtype, which is associated with unfavorable prognosis. Ets1 contributes to the acquisition of cancer cell invasiveness, to EMT (epithelial-to-mesenchymal transition), to the development of drug resistance and neo-angiogenesis. The aim of this review is to summarize the current knowledge on the functions of Etsl in carcinoma progression and on the mechanisms that regulate Etsl activity in cancer. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：20 / 38

页数：19

共 334 条

[1] Expanding the repertoire of an ERK2 recruitment site: Cysteine Footprinting identifies the D-recruitment site as a mediator of Ets-1 binding [J].

Abramczyk, Olga ;

Rainey, Mark A. ;

Barnes, Richard ;

Martin, Lance ;

Dalby, Kevin N. .

BIOCHEMISTRY, 2007, 46 (32) :9174-9186

[2] Ets-1 transcription is required in tissue factor driven microvessel formation and stabilization [J].

Arderiu, Gemma ;

Pena, Esther ;

Aledo, Rosa ;

Espinosa, Sonia ;

Badimon, Lina .

ANGIOGENESIS, 2012, 15 (04) :657-669

[3] Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: Correlation with microvessel density, progression, and prognosis [J].

Arora, S ;

Kaur, J ;

Sharma, C ;

Mathur, M ;

Bahadur, S ;

Shukla, NK ;

Deo, SVS ;

Ralhan, R .

CLINICAL CANCER RESEARCH, 2005, 11 (06) :2272-2284

[4] Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding [J].

Augustijn, KD ;

Duval, DL ;

Wechselberger, R ;

Kaptein, R ;

Gutierrez-Hartmann, A ;

van der Vliet, PC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12657-12662

[5] Structural Basis of Ets1 Cooperative Binding to Widely Separated Sites on Promoter DNA [J].

Babayeva, Nigar D. ;

Baranovskaya, Oxana I. ;

Tahirov, Tahir H. .

PLOS ONE, 2012, 7 (03)

[6] ETS-1 transcription factor binds cooperatively to the palindromic head to head ETS-binding sites of the stromelysin-1 promoter by counteracting autoinhibition [J].

Baillat, D ;

Bègue, A ;

Stéhelin, D ;

Aumercier, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :29386-29398

[7]

Ballschmieter P, 2003, INT J ONCOL, V22, P849

[8] Identification and dissection of a key enhancer mediating cranial neural crest specific expression of transcription factor, Ets-1 [J].

Barembaum, Meyer ;

Bronner, Marianne E. .

DEVELOPMENTAL BIOLOGY, 2013, 382 (02) :567-575

[9] Redox-sensitive gene-regulatory events controlling aberrant matrix metalloproteinase-1 expression [J].

Bartling, Toni R. ;

Subbaram, Sita ;

Clark, Ryan R. ;

Chandrasekaran, Akshaya ;

Kar, Supriya ;

Melendez, J. Andres .

FREE RADICAL BIOLOGY AND MEDICINE, 2014, 74 :99-107

[10] Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the ets 1 transcription factor in hnpcc carcinomas and sporadic colorectal cancers [J].

Behrens, P ;

Mathiak, M ;

Mangold, E ;

Kirdorf, S ;

Wellmann, A ;

Fogt, F ;

Rothe, M ;

Florin, A ;

Wernert, N .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (02) :183-188

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