Differences in gastric motor activity in renal transplant recipients treated with FK-506 versus cyclosporine

被引：51

作者：

Maes, BD ^{[1
]}

Vanwalleghem, J

Kuypers, D

Ghoos, Y

Rutgeerts, PJ

Vanrenterghem, YFC

机构：

[1] Univ Hosp Gasthuisberg, Dept Med, Div Nephrol, B-3000 Louvain, Belgium

[2] Univ Hosp Gasthuisberg, Dept Med, Div Gastroenterol, B-3000 Louvain, Belgium

[3] Univ Hosp Gasthuisberg, Gastrointestinal Res Ctr, B-3000 Louvain, Belgium

来源：

TRANSPLANTATION | 1999年 / 68卷 / 10期

关键词：

D O I：

10.1097/00007890-199911270-00009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background Little is known concerning gastric motility after renal transplantation and on the impact of immunosuppressants on gastric emptying. Methods. Gastric emptying was measured in renal transplant recipients, taking different immunosuppressive therapy (steroids and cyclosporine/azathioprine/FK-506), and compared with normal volunteers. Results After renal transplantation, gastric emptying of Liquids was normal, irrespective of the type of immunosuppression. However, solid gastric emptying was significantly faster in FK-506-treated patients compared with patients taking cyclosporine for all measured emptying parameters. Compared with normal volunteers solid gastric emptying was slower in patients taking cyclosporine, comparable in azathioprine treated patients, and characterized by an unusual short lag phase in patients taking FK-506. Conclusions. In stable renal transplant recipients gastric emptying of solids was significantly faster in patients on FK-506 compared with patients taking cyclosporine. Therefore, FK-506 may be the immunosuppressant of choice after solid organ transplantation in patients with problems related to gastroparesis.

引用

页码：1482 / 1485

页数：4

共 12 条

[1]

Costa A, 1996, TRANSPLANT P, V28, P2571

[2] IMPROVEMENT IN AUTONOMIC AND GASTRIC FUNCTION FOLLOWING PANCREAS-KIDNEY VERSUS KIDNEY-ALONE TRANSPLANTATION AND THE CORRELATION WITH QUALITY-OF-LIFE [J].

HATHAWAY, DK ;

ABELL, T ;

CARDOSO, S ;

HARTWIG, MS ;

ELGEBELY, S ;

GABER, AO .

TRANSPLANTATION, 1994, 57 (06) :816-822

[3]

IKOMA A, 1993, GASTROENTEROLOGY, V104, pA525

[4] IMPROVEMENT OF GASTRIC-EMPTYING IN DIABETIC GASTROPARESIS BY ERYTHROMYCIN - PRELIMINARY STUDIES [J].

JANSSENS, J ;

PEETERS, TL ;

VANTRAPPEN, G ;

TACK, J ;

URBAIN, JL ;

DEROO, M ;

MULS, E ;

BOUILLON, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (15) :1028-1031

[5]

MAES BD, 1994, J NUCL MED, V35, P824

[6] Gastric emptying rate of solids in patients with nonulcer dyspepsia [J].

Maes, BD ;

Ghoos, YF ;

Hiele, MI ;

Rutgeerts, PJ .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (06) :1158-1162

[7] INFLUENCE OF FOOD ON BIOAVAILABILITY OF DRUGS [J].

MELANDER, A .

CLINICAL PHARMACOKINETICS, 1978, 3 (05) :337-351

[8] ERYTHROMYCIN AND OTHER MACROLIDES AS PROKINETIC AGENTS [J].

PEETERS, TL .

GASTROENTEROLOGY, 1993, 105 (06) :1886-1899

[9] IMPORTANCE OF CHRONIC ASPIRATION IN RECIPIENTS OF HEART-LUNG TRANSPLANTS [J].

REID, KR ;

MCKENZIE, FN ;

MENKIS, AH ;

NOVICK, RJ ;

PFLUGFELDER, PW ;

KOSTUK, WJ ;

AHMAD, D .

LANCET, 1990, 336 (8709) :206-208

[10] MOTOR CYCLES WITH PHASE-III IN ANTRUM ARE ASSOCIATED WITH HIGH MOTILIN LEVELS AND PROLONGED GALLBLADDER EMPTYING [J].

STOLK, MFJ ;

VANERPECUM, KJ ;

SMOUT, AJPM ;

AKKERMANS, LMA ;

JANSEN, JBMJ ;

LAMERS, CBHW ;

PEETERS, TL ;

VANBERGEHENEGOUWEN, GP .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (04) :G596-G600

← 1 2 →