Copper/Diethyl Azodicarboxylate Mediated Regioselective Alkynylation Unactivated Aliphatic Tertiary Methylamine with Terminal Alkyne

被引：117

作者：

Xu, Xiaoliang ^{[1
]}

Li, Xiaonian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Inst Ind Catalysis, Hangzhou 310032, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

SP(3) C-H; BOND FORMATION; NITROGEN ATOM; OXIDATIVE ACTIVATION; FUNCTIONALIZATION; ADJACENT; ARENES; PROPARGYLAMINES; ALKENYLATION; CYCLOALKANES;

D O I：

10.1021/ol802974b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mediated by copper/diethyl azodicarboxylate, regioselective alkynylation of unactivated aliphatic tertiary methylamine with terminal alkyne was successfully established. It is not necessary for the tertiary methylamines to be aryl substituted to modulate the properties of amines. The alkynylation reaction described here has the advantage of simple operation, mild reaction conditions, good to excellent yields, and no need to exclude air and moisture.

引用

收藏

页码：1027 / 1029

页数：3

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