The mortal strand hypothesis: Non-random chromosome inheritance and the biased segregation of damaged DNA

被引：13
作者：
Charville, Gregory W. [1 ,2 ]
Rando, Thomas A. [1 ,3 ,4 ,5 ]
机构：
[1] Stanford Univ Sch Med, Paul F Glenn Labs Biol Aging, Stanford, CA 94305 USA
[2] Stanford Univ Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
[3] Stanford Univ Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[4] Vet Affairs Palo Alto Hlth Care Syst, Neurol Serv, Palo Alto, CA 94304 USA
[5] Vet Affairs Palo Alto Hlth Care Syst, Rehabil Res & Dev Ctr Excellence, Palo Alto, CA 94304 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2013年 / 24卷 / 8-9期
关键词：
Sister chromatids; Immortal strands; Mortal strands; Chromosomes; DNA damage; Stem cells; Asymmetric cell division; ASYMMETRIC CELL-DIVISION; STEM-CELLS; AURORA-A; CENTROSOME; PROTEINS; INSTABILITY; GAMMA-H2AX; ACTIVATION; CHECKPOINT; RENEWAL;
D O I：
10.1016/j.semcdb.2013.05.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
If a eukaryotic cell is to reproduce, it must duplicate its genetic information in the form of DNA, and faithfully segregate that information during a complex process of cell division. During this division process, the resulting cells inherit one, and only one, copy of each chromosome. Over thirty years ago, it was predicted that the segregation of sister chromosomes could occur non-randomly, such that a daughter cell would preferentially inherit one of the two sister chromosomes according to some characteristic of that chromosome's template DNA strand. Although this prediction has been confirmed in studies of various cell-types, we know little of both the mechanism by which the asymmetric inheritance occurs and the significance it has to cells. In this essay, we propose a new model of non-random chromosome segregation-the mortal strand hypothesis-and discuss tests of the model that will provide insight into the molecular choreography of this intriguing phenomenon. Published by Elsevier Ltd.
引用
收藏
页码：653 / 660
页数：8
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