Aberrant DNA Methylation in Human Cancers

被引：14

作者：

Li, Wen ^{[1
]}

Chen, Bi-feng ^{[2
]}

机构：

[1] Hubei Med Assoc, Editorial Dept Journal Clin Surg, Wuhan 430071, Peoples R China

[2] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2013年 / 33卷 / 06期

关键词：

epigenetics; aberrant DNA methylation; human cancers; treatment; TUMOR-SUPPRESSOR GENES; DE-NOVO METHYLATION; METHYLTRANSFERASE; LYSINE METHYLATION; BINDING PROTEINS; HUMAN BREAST; CPG ISLANDS; HYPOMETHYLATION; DNMT3A; EPIGENETICS;

D O I：

10.1007/s11596-013-1201-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation, one of the best-characterized epigenetic modifications, plays essential roles in diseases, including human cancers. In recent years, our understanding on DNA methylation with human cancers has made significant progress, which was facilitated by stunning development in the analysis of the human methylome of multiple cancer types. In this review, recent developments in the characterization of aberrant DNA methylation involved in human cancers development were discussed with special emphasis on the mechanisms of aberrant DNA methylation in human cancers. We also summarize the recent treatment strategy for human cancers with de-methylation drugs.

引用

页码：798 / 804

页数：7

共 69 条

[1] Multi-Targeted Histone Deacetylase Inhibitors in Cancer Therapy [J].

Ai, T. ;

Cui, H. ;

Chen, L. .

CURRENT MEDICINAL CHEMISTRY, 2012, 19 (04) :475-487

[2] DNA Methylation and Cancer Development: Molecular Mechanism [J].

Akhavan-Niaki, Haleh ;

Samadani, Ali Akbar .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2013, 67 (02) :501-513

[3] MicroRNA-Dependent Regulation of DNA Methyltransferase-1 and Tumor Suppressor Gene Expression by Interleukin-6 in Human Malignant Cholangiocytes [J].

Braconi, Chiara ;

Huang, Nianyuan ;

Patel, Tushar .

HEPATOLOGY, 2010, 51 (03) :881-890

[4]

Chen B-F, 2013, EPIGENETICS, V9, P1

[5] Preferential response of cancer cells to zebularine [J].

Cheng, JC ;

Yoo, CB ;

Weisenberger, DJ ;

Chuang, J ;

Wozniak, C ;

Liang, GN ;

Marquez, VE ;

Greer, S ;

Orntoft, TF ;

Thykjaer, T ;

Jones, PA .

CANCER CELL, 2004, 6 (02) :151-158

[6]

Cheng NC, 1996, ONCOGENE, V13, P1737

[7] A human modifier of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1 [J].

Cheng, NC ;

Chan, AJK ;

Beitsma, MM ;

Speleman, F ;

Westerveld, A ;

Versteeg, R .

HUMAN MOLECULAR GENETICS, 1996, 5 (03) :309-317

[8] DNA methylation and cancer [J].

Das, PM ;

Singal, R .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (22) :4632-4642

[9] Specific gene hypomethylation and cancer: New insights into coding region feature trends [J].

Daura-Oller, Elias ;

Cabre, Maria ;

Montero, Miguel A. ;

Paternain, Jose L. ;

Romeu, Antoni .

BIOINFORMATION, 2009, 3 (08) :340-343

[10] CpG islands and the regulation of transcription [J].

Deaton, Aimee M. ;

Bird, Adrian .

GENES & DEVELOPMENT, 2011, 25 (10) :1010-1022

← 1 2 3 4 5 6 7 →