A TGF-β pathway associated with cancer cachexia

被引：25

作者：

Guttridge, Denis C. ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med, Arthur G James Comprehens Canc Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

NATURE MEDICINE | 2015年 / 21卷 / 11期

关键词：

RELEASE CHANNELS; WEIGHT-LOSS; MUSCLE;

D O I：

10.1038/nm.3988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.

引用

页码：1248 / 1249

页数：2

共 9 条

[1] Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging [J].

Andersson, Daniel C. ;

Betzenhauser, Matthew J. ;

Reiken, Steven ;

Meli, Albano C. ;

Umanskaya, Alisa ;

Xie, Wenjun ;

Shiomi, Takayuki ;

Zalk, Ran ;

Lacampagne, Alain ;

Marks, Andrew R. .

CELL METABOLISM, 2011, 14 (02) :196-207

[2] Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle [J].

Bellinger, Andrew M. ;

Reiken, Steven ;

Carlson, Christian ;

Mongillo, Marco ;

Liu, Xiaoping ;

Rothman, Lisa ;

Matecki, Stefan ;

Lacampagne, Alain ;

Marks, Andrew R. .

NATURE MEDICINE, 2009, 15 (03) :325-330

[3]

Body J. J., 1999, Current Opinion in Oncology, V11, P255, DOI 10.1097/00001622-199907000-00004

[4] PROGNOSTIC EFFECT OF WEIGHT-LOSS PRIOR TO CHEMOTHERAPY IN CANCER-PATIENTS [J].

DEWYS, WD ;

BEGG, C ;

LAVIN, PT ;

BAND, PR ;

BENNETT, JM ;

BERTINO, JR ;

COHEN, MH ;

DOUGLASS, HO ;

ENGSTROM, PF ;

EZDINLI, EZ ;

HORTON, J ;

JOHNSON, GJ ;

MOERTEL, CG ;

OKEN, MM ;

PERLIA, C ;

ROSENBAUM, C ;

SILVERSTEIN, MN ;

SKEEL, RT .

AMERICAN JOURNAL OF MEDICINE, 1980, 69 (04) :491-497

[5] Definition and classification of cancer cachexia: an international consensus [J].

Fearon, Kenneth ;

Strasser, Florian ;

Anker, Stefan D. ;

Bosaeus, Ingvar ;

Bruera, Eduardo ;

Fainsinger, Robin L. ;

Jatoi, Aminah ;

Loprinzi, Charles ;

MacDonald, Neil ;

Mantovani, Giovanni ;

Davis, Mellar ;

Muscaritoli, Maurizio ;

Ottery, Faith ;

Radbruch, Lukas ;

Ravasco, Paula ;

Walsh, Declan ;

Wilcock, Andrew ;

Kaasa, Stein ;

Baracos, Vickie E. .

LANCET ONCOLOGY, 2011, 12 (05) :489-495

[6] The prevalence of concern about weight loss and change in eating habits in people with advanced cancer [J].

Hopkinson, Jane B. ;

Wright, David N. M. ;

McDonald, John W. ;

Corner, Jessica L. .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2006, 32 (04) :322-331

[7] Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors) [J].

Marx, SO ;

Ondrias, K ;

Marks, AR .

SCIENCE, 1998, 281 (5378) :818-821

[8] Excess TGF-β mediates muscle weakness associated with bone metastases in mice [J].

Waning, David L. ;

Mohammad, Khalid S. ;

Reiken, Steven ;

Xie, Wenjun ;

Andersson, Daniel C. ;

John, Sutha ;

Chiechi, Antonella ;

Wright, Laura E. ;

Umanskaya, Alisa ;

Niewolna, Maria ;

Trivedi, Trupti ;

Charkhzarrin, Sahba ;

Khatiwada, Pooja ;

Wronska, Anetta ;

Haynes, Ashley ;

Benassi, Maria Serena ;

Witzmannt, Frank A. ;

Zhen, Gehua ;

Wang, Xiao ;

Cao, Xu ;

Roodman, G. David ;

Marks, Andrew R. ;

Guise, Theresa A. .

NATURE MEDICINE, 2015, 21 (11) :1262-1271

[9]

Yachida S, 2009, ARCH PATHOL LAB MED, V133, P413, DOI 10.1043/1543-2165-133.3.413

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