Circadian regulation of auditory function

被引：43

作者：

Basinou, Vasiliki ^{[1
]}

Park, Jung-Sub ^{[1
,2
]}

Cederroth, Christopher R. ^{[1
]}

Canlon, Barbara ^{[1
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, Lab Expt Audiol, Von Eulers Vag 8, S-17177 Stockholm, Sweden

[2] Ajou Univ, Dept Otolaryngol, Sch Med, 164 Worldcup Ro, Suwon 16499, South Korea

来源：

HEARING RESEARCH | 2017年 / 347卷

基金：

英国医学研究理事会; 新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

SPIRAL GANGLION NEURONS; GENE-EXPRESSION; STARTLE REFLEX; CLOCK; TRANSCRIPTION; RHYTHMS; MOUSE; TIME; NEUROTROPHINS; OSCILLATORS;

D O I：

10.1016/j.heares.2016.08.018

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The circadian system integrates environmental cues to regulate physiological functions in a temporal fashion. The suprachiasmatic nucleus, located in the hypothalamus, is the master clock that synchronizes central and peripheral organ clocks to orchestrate physiological functions. Recently, molecular clock machinery has been identified in the cochlea unravelling the potential involvement in the circadian regulation of auditory functions. Here, we present background information on the circadian system and review the recent findings that introduce circadian rhythms to the auditory field. Understanding the mechanisms by which circadian rhythms regulate auditory function will provide fundamental knowledge on the signalling networks that control vulnerability and resilience to auditory insults. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：47 / 55

页数：9

共 68 条

[1] Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus [J].