Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa

被引：0

作者：

Dabitao, Djeneba ^{[1
,2
,3
]}

Dembele, Mamadou ^{[1
,2
]}

Urbanowski, Michael ^{[4
]}

Kone, Bourahima ^{[1
,2
]}

Wague, Mamadou ^{[1
,2
]}

Coulibaly, Nadie ^{[1
,2
]}

Sarro, Yeya Dit Sadio ^{[1
,2
]}

Baya, Bocar ^{[1
,2
]}

Goita, Drissa ^{[1
,2
]}

Dao, Sounkalo ^{[1
,2
]}

Belson, Michael ^{[5
]}

Klein, Sabra L. ^{[6
]}

Achenbach, Chad ^{[7
,8
,9
]}

Holl, Jane L. ^{[7
,8
,9
]}

Diakite, Mahamadou ^{[1
,2
]}

Doumbia, Seydou ^{[1
,2
]}

Bream, Jay H. ^{[6
,10
]}

Bishai, William R. ^{[4
]}

Diallo, Souleymane ^{[1
,2
]}

Murphy, Robert L. ^{[7
,8
,9
]}

机构：

[1] Univ Sci Tech & Technol Bamako USTTB, Univ Clin Res Ctr UCRC, Fac Pharm, BP 1805, Bamako, Mali

[2] Univ Sci Tech & Technol Bamako USTTB, Univ Clin Res Ctr UCRC, Fac Med & Odontostomatol, BP 1805, Bamako, Mali

[3] Northwestern Univ NU, Sch Profess Studies, Chicago, IL USA

[4] Johns Hopkins Sch Med, Ctr TB Res, Dept Infect Dis, Baltimore, MD USA

[5] NIAID, Collaborat Clin Res Branch CCRB, Div Clin Res DCR, 9000 Rockville Pike, Bethesda, MD 20892 USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA

[7] Northwestern Univ NU, Feinberg Sch Med, Div Infect Dis, Chicago, IL USA

[8] Northwestern Univ NU, Feinberg Sch Med, Inst Global Hlth, Chicago, IL USA

[9] Univ Chicago, Biol Sci Div, Chicago, IL 60637 USA

[10] Johns Hopkins Sch Med, Grad Program Immunol, Baltimore, MD USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2021年 / 37卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HIV; IL-10; genetics; SNPs; haplotypes; Mali; Africa; INTERLEUKIN-10; POLYMORPHISMS; ASSOCIATION; IL-10;

D O I：

10.1089/aid.2020.0140

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions -592 (C/A), -819 (C/T), and -1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

引用

页码：57 / 61

页数：5

共 15 条

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