共 27 条
Site of metastasis and breast cancer mortality: a Danish nationwide registry-based cohort study
被引:50
作者:
Ording, Anne Gulbech
[1
]
Heide-Jorgensen, Uffe
[1
]
Christiansen, Christian Fynbo
[1
]
Norgaard, Mette
[1
]
Acquavella, John
[2
]
Sorensen, Henrik Toft
[1
]
机构:
[1] Aarhus Univ Hosp, Dept Clin Epidemiol, Olof Palmes Alle 43-45, DK-8200 Aarhus N, Denmark
[2] Aarhus Univ, Dept Clin Epidemiol, Aarhus N, Denmark
关键词:
Breast neoplasm;
Neoplasm metastasis;
Prognosis;
Survival;
Epidemiology;
CNS METASTASES;
DE-NOVO;
SURVIVAL;
PROGNOSIS;
QUALITY;
EPIDEMIOLOGY;
HISTORY;
WOMEN;
D O I:
10.1007/s10585-016-9824-8
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Survival among patients with metastatic breast cancer may vary according to the site of metastasis and receptor status. We used Danish nationwide medical registries to establish a cohort of patients with metastatic breast cancer (870 with de novo metastatic disease and 3518 with recurrent disease with distant metastasis) diagnosed during 1997-2011. We examined 1-year and > 1 to 5-year mortality associated with first site of metastasis and receptor expression status of the primary tumor. Cox proportional regression was used to compute confounder-adjusted mortality rate ratios (MRRs) associated with site of metastasis, stratified by receptor status. Overall 1-year and > 1 to 5-year mortality risks were 36 and 69 %, respectively. Risk of death within 1 year was highest for brain-only (62 %) and liver-only (43 %) involvement and nearly the same for patients with lung-only (32 %), bone-only (32 %) involvement, and other/combination of sites (34 %). Using bone-only metastasis as reference, women with brain-only metastasis had more than two-fold increased risk of dying. The adjusted MRR for women with liver-only metastasis also was increased, though less pronounced. Patients with lung-only [adjusted MRR 0.9 (95 % confidence interval (CI) 0.8, 1.1)] or other metastases [adjusted MRR 1.0 (95 % CI 0.9, 1.2)] had similar mortality as patients with bone-only metastasis. Positive hormonal receptor status was a favorable prognostic factor. Metastatic breast cancer has a serious prognosis. Patients with brain-only metastasis had the highest mortality. Positive hormonal receptor status on the primary tumor was a favorable prognostic factor for all metastatic sites.
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页码:93 / 101
页数:9
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