Studies on anti-inflammatory drugs of 2-arylpropanoic acids: Part IX - A practical synthesis of ketoprofen by 1,2-aryl rearrangement

被引：0
|
作者：
Chen, FN [1 ]
Liu, JD [1 ]
Sho, LY [1 ]
Yan, QJ [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1999年 / 38卷 / 08期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of ketoprofen via chloration, Friedel-Crafts acylation, reduction, coupling, ketalization, rearrangement, hydrolysis and oxidation from commercially available bromo-benzoic acid in overall yield of about 60% has been described.
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页码：989 / 992
页数：4
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