Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis

被引：2

作者：

Shi, Wei ^{[1
]}

Hu, Jiangfeng ^{[2
]}

Zhu, Shizhang ^{[3
]}

Shen, Xiaoying ^{[3
]}

Zhang, Xiaoyan ^{[3
]}

Yang, Changqing ^{[2
]}

Gao, Hengjun ^{[2
,3
]}

Zhang, Hao ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R China

[2] Tongji Univ, Tongji Hosp, Dept Gastroenterol, Shanghai 200065, Peoples R China

[3] Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 10期

基金：

美国国家科学基金会;

关键词：

MTA2; Ki-67; HCC; liver cancer; GENE-EXPRESSION; CANCER METASTASIS; OVEREXPRESSION; INVASION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.

引用

页码：13083 / 13089

页数：7

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