Pharmacological Potential of Sea Cucumbers

被引：126

作者：

Khotimchenko, Yuri ^{[1
,2
]}

机构：

[1] Far Eastern Fed Univ, Sch Biomed, 8 Ul Sukhanova, Vladivostok 690950, Russia

[2] Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok 690041, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

Echinodermata; Holothuroidea; sea cucumber; polysaccharides; fucosylated chondroitin sulfate; glycans; saponins; triterpene glycosides; ceramides; FUCOSYLATED CHONDROITIN SULFATE; CYTOTOXIC TRITERPENE GLYCOSIDES; DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN; FREE-RADICAL DEPOLYMERIZATION; LONG-CHAIN BASES; ANTICOAGULANT ACTIVITY; CUCUMARIA-FRONDOSA; IN-VIVO; ANTIOXIDANT PEPTIDES; BODY-WALL;

D O I：

10.3390/ijms19051342

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents a detailed analysis of published research data focused on the pharmacological activity exerted by biologically active compounds isolated from sea cucumbers belonging to the class of Holothuroidea, phylum Echinodermata. The review contains descriptions of the structure, physico-chemical properties and pharmacological effects of these active substances. Particular attention is given to compounds with anticoagulant, antithrombotic, antioxidant, anticancer, anti-infectious, immune-stimulating and anti-ACE (angiotensin converting enzyme) activities as well as to the substances exerting a regulating influence on lipid and carbohydrate metabolism. All these compounds may be considered as prototypes for development of new pharmaceutical substances and medicines.

引用

页数：42

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