Molecular action mechanisms of solar infrared radiation and heat on human skin

被引:104
作者
Akhalaya, M. Ya. [1 ]
Maksimov, G. V. [1 ]
Rubin, A. B. [1 ]
Lademann, J. [2 ]
Darvin, M. E. [2 ]
机构
[1] Moscow MV Lomonosov State Univ, Fac Biol, Dept Biophys, Moscow 119991, Russia
[2] Charite, Dept Dermatol Venerol & Allergol, Ctr Expt & Appl Cutaneous Physiol, D-10117 Berlin, Germany
关键词
Skin aging; Antioxidants; Free radicals; Pathways; Safety doses; LEVEL LASER THERAPY; RAMAN-SPECTROSCOPIC ANALYSIS; IN-VIVO; IR RADIATION; RADICAL PROTECTION; VISIBLE-LIGHT; METALLOPROTEINASE-1; EXPRESSION; ULTRAVIOLET-RADIATION; MUSCLE PERFORMANCE; MMP-1;
D O I
10.1016/j.arr.2014.03.006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The generation of ROS underlies all solar infrared-affected therapeutic and pathological cutaneous effects. The signaling pathway NF-kB is responsible for the induced therapeutic effects, while the AP-1 for the pathological effects. The different signaling pathways of infrared-induced ROS and infrared-induced heat shock ROS were shown to act independently multiplying the influence on each other by increasing the doses of irradiation and/or increasing the temperature. The molecular action mechanisms of solar infrared radiation and heat on human skin are summarized and discussed in detail in the present paper. The critical doses are determined. Protection strategies against infrared-induced skin damage are proposed. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 11
页数:11
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