Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
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Manokruang, Kiattikhun
[1
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Lym, Jae Seung
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Sungkyunkwan Univ, Sch Chem Engn, Theranost Macromol Res Ctr, Suwon 440746, Gyeonggi Do, South KoreaChiang Mai Univ, Fac Sci, Dept Chem & Mat Sci, Res Ctr, Chiang Mai 50200, Thailand
Lym, Jae Seung
[2
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Lee, Doo Sung
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Sungkyunkwan Univ, Sch Chem Engn, Theranost Macromol Res Ctr, Suwon 440746, Gyeonggi Do, South KoreaChiang Mai Univ, Fac Sci, Dept Chem & Mat Sci, Res Ctr, Chiang Mai 50200, Thailand
Lee, Doo Sung
[2
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[1] Chiang Mai Univ, Fac Sci, Dept Chem & Mat Sci, Res Ctr, Chiang Mai 50200, Thailand
[2] Sungkyunkwan Univ, Sch Chem Engn, Theranost Macromol Res Ctr, Suwon 440746, Gyeonggi Do, South Korea
Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. (C) 2014 Elsevier RV. All rights reserved.
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Sungkyunkwan Univ, Dept Polymer Sci & Chem Engn, Theranost Macromol Res Ctr, Suwon Gyeonggi Do 440746, South KoreaChiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
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Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, ThailandChiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
Rapeekan, Jirathititiporn
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Songtipya, Ponusa
Lee, Doo Sung
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Sungkyunkwan Univ, Sch Chem Engn, Theranost Macromol Res Ctr, Suwon Gyeonggi Do 16419, South KoreaChiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
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Sungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South KoreaSungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South Korea
Phan, V. H. Giang
Thambi, Thavasyappan
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Sungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South KoreaSungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South Korea
Thambi, Thavasyappan
Huu Thuy Trang Duong
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Sungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South KoreaSungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South Korea
Huu Thuy Trang Duong
Lee, Doo Sung
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Sungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South KoreaSungkyunkwan Univ, Theranost Macromol Res Ctr, Sch Chem Engn, Suwon, South Korea
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Bercea, Maria
Plugariu, Ioana-Alexandra
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Plugariu, Ioana-Alexandra
Dinu, Maria Valentina
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Dinu, Maria Valentina
Pelin, Irina Mihaela
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Pelin, Irina Mihaela
Lupu, Alexandra
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Lupu, Alexandra
Bele, Adrian
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Petru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania
Bele, Adrian
Gradinaru, Vasile Robert
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Alexandru Ioan Cuza Univ, Fac Chem, 11 Carol I Bd, Iasi 700506, RomaniaPetru Poni Inst Macromol Chem, 41-A Grigore Ghica Voda Alley, Iasi 700487, Romania