Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin

被引:7
|
作者
Manokruang, Kiattikhun [1 ]
Lym, Jae Seung [2 ]
Lee, Doo Sung [2 ]
机构
[1] Chiang Mai Univ, Fac Sci, Dept Chem & Mat Sci, Res Ctr, Chiang Mai 50200, Thailand
[2] Sungkyunkwan Univ, Sch Chem Engn, Theranost Macromol Res Ctr, Suwon 440746, Gyeonggi Do, South Korea
基金
新加坡国家研究基金会;
关键词
pH/temperature sensitive polymers; Injectable hydrogels; Polyurethane; Bovine serum albumin; COPOLYMER HYDROGELS; DRUG-DELIVERY; BLOCK-COPOLYMER; CARRIER;
D O I
10.1016/j.matlet.2014.03.052
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. (C) 2014 Elsevier RV. All rights reserved.
引用
收藏
页码:105 / 109
页数:5
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