Application of thermogravimetry in the quality control of chloramphenicol tablets

被引：25

作者：

Macêdo, RO ^{[1
]}

Aragao, CFS ^{[1
]}

do Nascimento, TG ^{[1
]}

Macêdo, AMC ^{[1
]}

机构：

[1] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58059900 Joao Pessoa, Paraiba, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 1999年 / 56卷 / 03期

关键词：

chloramphenicol; DSC; quality central; TG;

D O I：

10.1023/A:1010102422381

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The stability and thermal behaviour of chloramphenicol and various of its mixtures were investigated. The thermogravimetric and stability constant results showed that the chloramphenicol base is thermally more stable than the tablet in the studied formulation. The reduction in stability was attributed to the presence of search in the formulation. The thermal decompositions of the chloramphenicol base and the tablet obey first-order kinetics.

引用

页码：1323 / 1327

页数：5

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