Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

被引：124
作者：
Xu, Leyuan [1 ]
Zhang, Hao [2 ]
Wu, Yue [3 ]
机构：
[1] Virginia Commonwealth Univ, Dept Biomed Engn, Richmond, VA 23284 USA
[2] Virginia Commonwealth Univ, Dept Mech & Nucl Engn, Richmond, VA 23284 USA
[3] Virginia Commonwealth Univ, Dept Chem & Life Sci Engn, Richmond, VA 23284 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2014年 / 5卷 / 01期
基金：
美国国家科学基金会;
关键词：
Dendrimer; drug delivery; central nervous system; blood-brain barrier; brain targeting; BLOOD-BRAIN-BARRIER; AMYLOID-INDUCED TOXICITY; NEUTRON-CAPTURE THERAPY; EPIDERMAL-GROWTH-FACTOR; IN-VIVO; GENE DELIVERY; POLY(AMIDOAMINE) DENDRIMERS; CNS DELIVERY; POLYAMIDOAMINE DENDRIMERS; PAMAM DENDRIMERS;
D O I：
10.1021/cn400182z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs cannot permeate into the brain parenchyma because of the blood-brain barrier (BBB), and overcoming this has become one of the most significant challenges in the development of CNS therapeutics. Rapid advances in nanotechnology have provided promising solutions to this challenge. This review discusses the latest applications of dendrimers in the treatment of CNS diseases with an emphasis on brain tumors. Dendrimer-mediated drug delivery, imaging, and diagnosis are also reviewed. The toxicity, biodistribution, and transport mechanisms in dendrimer-mediated delivery of CNS therapeutic agents bypassing or crossing the BBB are also discussed. Future directions and major challenges of dendrimer-mediated delivery of CNS therapeutic agents are included.
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收藏
页码：2 / 13
页数：12
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