A new synthesis of caged GABA compounds for studying GABAA receptors

被引：11

作者：

Fan, Lijun ^{[1
]}

Lewis, Ryan W. ^{[2
]}

Hess, George P. ^{[2
]}

Ganem, Bruce ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Chem Biol, Baker Lab, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 14期

关键词：

GABA; Neurotransmitter; Caged compound; Synthesis; EPILEPSY;

D O I：

10.1016/j.bmcl.2009.03.065

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarization measurements on the mammalian GABA(A) receptor. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3932 / 3933

页数：2

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