Early clinical trial concept for boron neutron capture therapy: A critical assessment of the EORTC trial 11001

被引：19

作者：

Wittig, A. ^{[1
]}

Collette, L. ^{[2
]}

Moss, R. ^{[3
]}

Sauerwein, W. A. ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Radiat Oncol, Essen, Germany

[2] EORTC, Dept Stat, Brussels, Belgium

[3] European Commiss, Joint Res Ctr, Inst Energy, HFR Unit, Petten, Netherlands

来源：

APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 7-8期

关键词：

Binary treatment modality; Early clinical trials; Radiotherapy; Trial design; Boron neutron capture therapy (BNCT); BSH; BPA; LIVER METASTASES; BNCT; CANCER; BIODISTRIBUTION; ADENOCARCINOMA; TISSUE; HEAD;

D O I：

10.1016/j.apradiso.2009.03.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

BNCT causes selective damage to tumor cells by neutron capture reactions releasing high LET-particles where (10)B-atoms are present. Neither the (10)B-compound nor thermal neutrons alone have any therapeutic effect. Therefore, the development of BNCT to a treatment modality needs strategies, which differ from the standard phase I-III clinical trials. An innovative trial design was developed including translational research and a phase I aspect. The trial investigates as surrogate endpoint BSH and BPA uptake in different tumor entities. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：S59 / S62

页数：4

共 15 条

[1] First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA pet
Aihara, Teruhito
Hiratsuka, Junichi
Morita, Norimasa
Uno, Masako
Sakurai, Yoshinori
Maruhashi, Akira
Ono, Koji
Harada, Tamotsu
[J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (09): : 850 - 855
[2] A critical examination of the results from the Harvard-MIT NCT program phase I clinical trial of neutron capture therapy for intracranial disease
Busse, PM
Harling, OK
Palmer, MR
Kiger, WS
Kaplan, J
Kaplan, I
Chuang, CF
Goorley, JT
Riley, KJ
Newton, TH
Santa Cruz, GA
Lu, X
Zamenhof, RG
[J]. JOURNAL OF NEURO-ONCOLOGY, 2003, 62 (01) : 111 - 121
[3] Biodistribution of p-borophenylalanine (BPA) in dogs with spontaneous undifferentiated thyroid carcinoma (UTC)
Dagrosa, MA
Viaggi, M
Rebagliati, RJ
Castillo, VA
Batistoni, D
Cabrini, RL
Castiglia, S
Juvenal, GJ
Pisarev, MA
[J]. APPLIED RADIATION AND ISOTOPES, 2004, 61 (05) : 911 - 915
[4] Optimization of boron neutron capture therapy for the treatment of undifferentiated thyroid cancer
Dagrosa, Maria Alejandra
Thomasz, Lisa
Longhino, Juan
Perona, Marina
Calzetta, Osvaldo
Blaumann, Herman
Rebagliati, Raul Jimenez
Cabrini, Romulo
Kahl, Steven
Juvenal, Guillermo Juan
Pisarev, Mario Alberto
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (04): : 1059 - 1066
[5] European Commission, RUL GOV MED PROD EUR
[6] Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
Heber, E
Trivillin, VA
Nigg, D
Kreimann, EL
Itoiz, ME
Rebagliati, RJ
Batistoni, D
Schwint, AE
[J]. ARCHIVES OF ORAL BIOLOGY, 2004, 49 (04) : 313 - 324
[7] Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial
Hideghéty, K
Sauerwein, W
Wittig, A
Götz, C
Paquis, P
Grochulla, F
Haselsberger, K
Wolbers, J
Moss, R
Huiskamp, R
Fankhauser, H
de Vries, M
Gabel, D
[J]. JOURNAL OF NEURO-ONCOLOGY, 2003, 62 (01) : 145 - 156
[8] Boron neutron capture therapy in the treatment of locally recurred head and neck cancer
Kankaanranta, Leena
Seppala, Tiina
Koivunoro, Hanna
Saarilahti, Kauko
Atula, Timo
Collan, Juhani
Salli, Eero
Kortesniemi, Mika
Uusi-Simola, Jouni
Makitle, Antti
Seppanen, Marko
Minn, Heikki
Kotiluoto, Petri
Auterinen, Iiro
Savolainen, Sauli
Kouri, Mauri
Joensuu, Heikki
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (02): : 475 - 482
[9] Nano R, 2004, ONCOL REP, V11, P149
[10] Sauerwein W, 2002, EUR J CANCER, V38, pS31

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