Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

被引：94
作者：
Ali, Ayesha [1 ,2 ]
Tan, HuiYing [1 ,2 ]
Kaiko, Gerard E. [1 ,2 ]
机构：
[1] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia
[2] Hunter Med Res Inst, Newcastle, NSW, Australia
来源：
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
epithelium; microbiota; allergy; anaphyalaxis; intestinal immunity; TIGHT JUNCTION PERMEABILITY; IN-VITRO MODEL; DENDRITIC CELLS; GUT PERMEABILITY; BARRIER FUNCTION; ENDOCRINE CELL; MUCUS LAYERS; TUFT CELLS; T-CELLS; BACTERIA;
D O I：
10.3389/fimmu.2020.604054
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.
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