Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

被引：94

作者：

Ali, Ayesha ^{[1
,2
]}

Tan, HuiYing ^{[1
,2
]}

Kaiko, Gerard E. ^{[1
,2
]}

机构：

[1] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia

[2] Hunter Med Res Inst, Newcastle, NSW, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

epithelium; microbiota; allergy; anaphyalaxis; intestinal immunity; TIGHT JUNCTION PERMEABILITY; IN-VITRO MODEL; DENDRITIC CELLS; GUT PERMEABILITY; BARRIER FUNCTION; ENDOCRINE CELL; MUCUS LAYERS; TUFT CELLS; T-CELLS; BACTERIA;

D O I：

10.3389/fimmu.2020.604054

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.

引用

页数：12

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