Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

被引：86
作者：
Ali, Ayesha [1 ,2 ]
Tan, HuiYing [1 ,2 ]
Kaiko, Gerard E. [1 ,2 ]
机构：
[1] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia
[2] Hunter Med Res Inst, Newcastle, NSW, Australia
来源：
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
epithelium; microbiota; allergy; anaphyalaxis; intestinal immunity; TIGHT JUNCTION PERMEABILITY; IN-VITRO MODEL; DENDRITIC CELLS; GUT PERMEABILITY; BARRIER FUNCTION; ENDOCRINE CELL; MUCUS LAYERS; TUFT CELLS; T-CELLS; BACTERIA;
D O I：
10.3389/fimmu.2020.604054
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.
引用
收藏
页数：12
相关论文
共 136 条
  • [1] Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
    Agus, Allison
    Planchais, Julien
    Sokol, Harry
    [J]. CELL HOST & MICROBE, 2018, 23 (06) : 716 - 724
  • [2] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    Arpaia, Nicholas
    Campbell, Clarissa
    Fan, Xiying
    Dikiy, Stanislav
    van der Veeken, Joris
    deRoos, Paul
    Liu, Hui
    Cross, Justin R.
    Pfeffer, Klaus
    Coffer, Paul J.
    Rudensky, Alexander Y.
    [J]. NATURE, 2013, 504 (7480) : 451 - +
  • [3] The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo
    Atuma, C
    Strugala, V
    Allen, A
    Holm, L
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (05): : G922 - G929
  • [4] Modulation of mouse Paneth cell α-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel
    Ayabe, T
    Wulff, H
    Darmoul, D
    Cahalan, MD
    Chandy, KG
    Ouellette, AJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (05) : 3793 - 3800
  • [5] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases
    Bach, JF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) : 911 - 920
  • [6] Histamine-secreting microbes are increased in the gut of adult asthma patients
    Barcik, Weronika
    Pugin, Benoit
    Westermann, Patrick
    Perez, Noelia Rodriguez
    Ferstl, Ruth
    Wawrzyniak, Marcin
    Smolinska, Sylwia
    Jutel, Marek
    Hessel, Edith M.
    Michalovich, David
    Akdis, Cezmi A.
    Frei, Remo
    O'Mahony, Liam
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (05) : 1491 - 1494
  • [7] The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
    Beeh, Kai-Michael
    Kanniess, Frank
    Wagner, Frank
    Schilder, Cordula
    Naudts, Ingomar
    Hammann-Haenni, Anya
    Willers, Joerg
    Stocker, Hans
    Mueller, Philipp
    Bachmann, Martin F.
    Renner, Wolfgang A.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (03) : 866 - 874
  • [8] Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions
    Boonekamp, Kim E.
    Dayton, Talya L.
    Clevers, Hans
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 12 (08) : 562 - 568
  • [9] Regulatory role of suppressive motifs from commensal DNA
    Bouladoux, N.
    Hall, J. A.
    Grainger, J. R.
    dos Santos, L. M.
    Kann, M. G.
    Nagarajan, V.
    Verthelyi, D.
    Belkaid, Y.
    [J]. MUCOSAL IMMUNOLOGY, 2012, 5 (06) : 623 - 634
  • [10] Breiteneder H, 2004, J ALLERGY CLIN IMMUN, V113, P821, DOI [10.1016/j.jaci.2004.01.079, 10.1016/j.jaci.2004.01.779]
12345678910