Synthesis and Antimicrobial Activity of 5-Imidazolinone Derivatives

被引：34

作者：

Desai, N. C. ^{[1
]}

Bhavsar, A. M. ^{[1
]}

Baldaniya, B. B. ^{[1
]}

机构：

[1] Bhavnagar Univ, Univ Dept Chem, Div Med Chem, Bhavnagar 364002, Gujarat, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 71卷 / 01期

关键词：

5-Imidazolinone; antibacterial activity; antifungal activity; ANTI-HIV AGENTS; ANTICANCER;

D O I：

10.4103/0250-474X.51953

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of OH, OCH3, NO2, Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

引用

页码：90 / 94

页数：5

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