Correlation between mimecan expression and coronary artery stenosis in patients with coronary heart disease

被引:0
作者
Hu, Youdong [1 ]
Liu, Junying [1 ]
Zhao, Qingna [1 ]
Xu, Peijing [1 ]
Chen, Ying [1 ]
Zhou, Hualan [1 ]
Li, Xia [1 ]
机构
[1] Xuzhou Med Collage, Dept Geriatr, Affiliated Huaiai Hosp, Huaian, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 11期
关键词
Mimecan gene; nuclear factor kappa B; coronary heart disease; coronary artery stenosis; NF-KAPPA-B; DIFFERENTIAL EXPRESSION; ATHEROSCLEROTIC PLAQUES; INFLAMMATION; OSTEOGLYCIN; MATRIX; ARTERIOGENESIS; PROTEOGLYCAN; MACROPHAGES; ACTIVATION;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: This study aimed to investigate the correlation between coronary artery stenosis and Mimecan expression in patients with coronary heart disease (CHD). Methods: Seventy eight patients with CHD and 80 controls without vascular lesions were recruited into present study. CHD patients were divided into one-vessel CHD subgroup, 2-vessel CHD subgroup and multivessel CHD subgroup. ELISA was performed to detect the expressions of serum Mimecan and nuclear factor kappaB (NF-kappa B). Results: When compared with control group, the expressions of serum mimecan gene and NF-kappa B significantly increased in CHD groups (P < 0.05); When compared with one-vessel and two-vessel CHD subgroups, the expressions of serum mimecan and NF-kappa B significantly increased in multivessel CHD subgroup (P < 0.05), significant difference was observed among three subgroups (P < 0.05). The expressions of serum mimecan and NF-kappa B were positively related to the severity of coronary lesions (r(mimecan) = 0.79, r(NF-kappa B) = 0.83, P < 0.05). Conclusion: Increased expressions of serum mimecan and NF-kappa B in CHD patients are related to cardiac insufficiency, which may be ascribed to the binding of NF-kappa B to mimecan gene.
引用
收藏
页码:21641 / 21646
页数:6
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