Human epigenetic ageing is logarithmic with time across the entire lifespan

被引：39

作者：

Snir, Sagi ^{[1
]}

Farrell, Colin ^{[2
]}

Pellegrini, Matteo ^{[2
]}

机构：

[1] Univ Haifa, Dept Evolutionary Biol, Haifa, Israel

[2] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

来源：

EPIGENETICS | 2019年 / 14卷 / 09期

关键词：

Aging; DNA methylation; DNA METHYLATION; AGE; PACEMAKER;

D O I：

10.1080/15592294.2019.1623634

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic changes during ageing have been characterized by multiple epigenetic clocks that allow the prediction of chronological age based on methylation status. Despite their accuracy and utility, epigenetic age biomarkers leave many questions about epigenetic ageing unanswered. Specifically, they do not permit the unbiased characterization of non-linear epigenetic ageing trends across entire life spans, a critical question underlying this field of research. Here we provide an integrated framework to address this question. Our model, inspired from evolutionary models, is able to account for acceleration/deceleration in epigenetic changes by fitting an individual's model age, the epigenetic age, which is related to chronological age in a non-linear fashion. Application of this model to DNA methylation data measured across broad age ranges, from before birth to old age, and from two tissue types, suggests a universal logarithmic trend characterizes epigenetic ageing across entire lifespans.

引用

页码：912 / 926

页数：15

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