8-Hydroxy-2′-deoxyguanosine expression predicts outcome of esophageal cancer

被引：23

作者：

He, Hongtao ^{[1
]}

Zhao, Yufei ^{[1
]}

Wang, Na ^{[1
]}

Zhang, Lan ^{[1
]}

Wang, Cuiju ^{[2
]}

机构：

[1] Dept Gastroenterol & Hepatol, Shijiazhuang, Peoples R China

[2] Dept Gynecol Ultrasound, Shijiazhuang, Peoples R China

来源：

ANNALS OF DIAGNOSTIC PATHOLOGY | 2014年 / 18卷 / 06期

关键词：

8-OHdG; Esophageal cancer; Outcome; Survival; OXIDATIVE DNA-DAMAGE; SQUAMOUS-CELL CARCINOMA; URINARY; 8-HYDROXY-2-DEOXYGUANOSINE; HEPATOCELLULAR-CARCINOMA; STRESS; CARCINOGENESIS; ENZYME; MARKER;

D O I：

10.1016/j.anndiagpath.2014.08.008

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Esophageal cancer is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA. We analyzed the predictive value of 8-OHdG expression on postoperative survival of patients with esophageal cancer with univariate and multivariate analysis. The high levels of 8-OHdG are associated with significantly shorter survival time by log-rank test using Kaplan-Meier methods. Moreover, the level of 8-OHdG expression was identified as an independent predictor for esophageal cancer outcome using Cox proportional hazards model analysis (relative risk, 0294; 95% confidence interval, 0.178-0.487; P = .000). These results suggest that oxidative damage marker of 8-OHdG is a useful prognostic marker in esophageal cancer. The analysis of 8-OHdG levels can help in the identification of patient subgroups that are at high risk for poor disease outcomes (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：326 / 328

页数：3

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