Steroid-sparing Effects of Etanercept in a Patient with Steroid-dependent Adult-onset Still's Disease

被引：8

作者：

Kiyonaga, Yasuhiro ^{[1
]}

Maeshima, Keisuke ^{[1
]}

Imada, Chiharu ^{[1
]}

Haranaka, Miwa ^{[1
]}

Ishii, Koji ^{[1
]}

Shibata, Hirotaka ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Endocrinol Metab Rheumatol & Nephrol, Oita, Japan

来源：

INTERNAL MEDICINE | 2014年 / 53卷 / 11期

关键词：

adult-onset Still's disease (AOSD); steroid-sparing effect; etanercept; elderly patient; MACROPHAGE ACTIVATION SYNDROME; TUMOR-NECROSIS-FACTOR; OF-THE-LITERATURE; RHEUMATOID-ARTHRITIS; BIOLOGIC AGENTS; ANAKINRA; THERAPY; TOCILIZUMAB; TNF; METHOTREXATE;

D O I：

10.2169/internalmedicine.53.1488

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report the case of an 84-year-old man with steroid-dependent adult-onset Still's disease (AOSD) whose daily steroid dose was successfully tapered after etanercept treatment. The corticosteroids worked well initially, and the patient went into remission promptly; however, he suffered a relapse due to steroid tapering. Because treatment with cyclosporine and methotrexate was ineffective, reducing the steroid dose was difficult, and the corticosteroids induced myopathy and diabetes. However, steroid tapering was accomplished in combination with etanercept therapy, and the patient's steroid-induced side effects disappeared. Etanercept should therefore be considered as a steroid-sparing treatment option in patients with steroid-responsive, steroid-dependent AOSD.

引用

页码：1209 / 1213

页数：5

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