Metabolic profiling investigation of Fritillaria thunbergii Miq. by gas chromatography-mass spectrometry

被引：31

作者：

Cui, Ming-Chao ^{[1
,2
]}

Chen, Shao-Jun ^{[2
]}

Wang, Han-Hua ^{[2
]}

Li, Zhao-Hui ^{[2
]}

Chen, Hong-Jiang ^{[1
,2
]}

Chen, Yong ^{[1
]}

Zhou, Hai-Bin ^{[3
]}

Li, Xiang ^{[1
]}

Chen, Jian-Wei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Pharm, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China

[2] Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, 888 Yinxian Rd, Ningbo 315100, Zhejiang, Peoples R China

[3] Ningbo Liwah Pharmaceut Co Ltd, Ningbo 315174, Zhejiang, Peoples R China

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 2018年 / 26卷 / 01期

关键词：

Fritillaria thunbergii Miq; gas chromatography-mass spectrometry; metabolomics;

D O I：

10.1016/j.jfda.2016.10.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Thunberg fritillary bulb (the dry bulbs of Fritillaria thunbergii Miq.), a traditional Chinese Medicine, is widely applied as an expectorant and antitussive. In this investigation, the primary metabolites of bulbs, flowers, leaves, and stems of F. thunbergii were analyzed by gas chromatography-mass spectrometry. Principal component analysis, partial least squares-discriminate analysis, orthogonal projection to latent structures-discriminate analysis, and heat map analysis showed that there were dissimilar metabolites, and a negative correlation between amino acids and saccharides in different analytes. Furthermore, carbodiimide, tryptophan, glucose-6-phosphate, xylose, 2-piperidinecarboxylic acid, monoamidomalonic acid, phenylalanine, and histidine were found to play an important role in the plant metabolism net of F. thunbergii. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.

引用

页码：337 / 347

页数：11

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