Acute kidney injury: from creatinine to KIM-1?

被引:0
作者
Wallbach, M. [1 ]
Tampe, B. [1 ]
Dihazi, H. [1 ]
Koziolek, M. J. [1 ]
机构
[1] Univ Med Gottingen, Klin Nephrol & Rheumatol, Robert Koch Str 40, D-37075 Gottingen, Germany
来源
INTERNIST | 2019年 / 60卷 / 06期
关键词
Biomarkers; Epigenetics; Kidney damage; functional; Proteomics; structural; GELATINASE-ASSOCIATED LIPOCALIN; RENAL REPLACEMENT THERAPY; DNA METHYLTRANSFERASE; BIOMARKERS; METABOLOMICS; AKI; PREDICTION; MARKER; HYDROXYMETHYLATION; IDENTIFICATION;
D O I
10.1007/s00108-019-0602-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In addition to the early detection of an acute kidney injury (AKI), several problems or questions have to be addressed. These include the identification of the etiology, the severity (functional or structural), the prognosis (recovery or transition to chronic renal failure), the course of the disease (dialysis or not), and the identification of specific treatment options for AKI. The following article provides an overview of established and new AKI biomarkers as well as an outlook on the potential of future biomarker-associated models of AKI.
引用
收藏
页码:578 / 586
页数:9
相关论文
共 58 条
[1]   Biomarkers of AKI: A Review of Mechanistic Relevance and Potential Therapeutic Implications [J].
Alge, Joseph L. ;
Arthur, John M. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 10 (01) :147-155
[2]   MG98, a Second-Generation DNMT1 Inhibitor, in the Treatment of Advanced Renal Cell Carcinoma [J].
Amato, Robert J. ;
Stephenson, Joe ;
Hotte, Sebastien ;
Nemunaitis, John ;
Belanger, Karl ;
Reid, Gregory ;
Martell, Robert E. .
CANCER INVESTIGATION, 2012, 30 (05) :415-421
[3]   Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery [J].
Arthur, John M. ;
Hill, Elizabeth G. ;
Alge, Joseph L. ;
Lewis, Evelyn C. ;
Neely, Benjamin A. ;
Janech, Michael G. ;
Tumlin, James A. ;
Chawla, Lakhmir S. ;
Shaw, Andrew D. .
KIDNEY INTERNATIONAL, 2014, 85 (02) :431-438
[4]   Early Nephrologist Involvement in Hospital-Acquired Acute Kidney Injury: A Pilot Study [J].
Balasubramanian, Geetha ;
Al-Aly, Ziyad ;
Moiz, Abdul ;
Rauchman, Michael ;
Zhang, Zhiwei ;
Gopalakrishnan, Rajalakshmi ;
Balasubramanian, Sumitra ;
El-Achkar, Tarek M. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2011, 57 (02) :228-234
[5]   Methylation determines fibroblast activation and fibrogenesis in the kidney [J].
Bechtel, Wibke ;
McGoohan, Scott ;
Zeisberg, Elisabeth M. ;
Mueller, Gerhard A. ;
Kalbacher, Hubert ;
Salant, David J. ;
Mueller, Claudia A. ;
Kalluri, Raghu ;
Zeisberg, Michael .
NATURE MEDICINE, 2010, 16 (05) :544-U75
[6]   Next-generation biomarkers for detecting kidney toxicity [J].
Bonventre, Joseph V. ;
Vaidya, Vishal S. ;
Schmouder, Robert ;
Feig, Peter ;
Dieterle, Frank .
NATURE BIOTECHNOLOGY, 2010, 28 (05) :436-440
[7]   DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys [J].
Chang, Yu-Ting ;
Yang, Ching-Chin ;
Pan, Szu-Yu ;
Chou, Yu-Hsiang ;
Chang, Fan-Chi ;
Lai, Chun-Fu ;
Tsai, Ming-Hsuan ;
Hsu, Huan-Lun ;
Lin, Ching-Hung ;
Chiang, Wen-Chih ;
Wu, Ming-Shiou ;
Chu, Tzong-Shinn ;
Chen, Yung-Ming ;
Lin, Shuei-Long .
JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (02) :721-731
[8]   Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine [J].
Delanaye, Pierre ;
Cavalier, Etienne ;
Morel, Jerome ;
Mehdi, Manolie ;
Maillard, Nicolas ;
Claisse, Guillaume ;
Lambermont, Bernard ;
Dubois, Bernard E. ;
Damas, Pierre ;
Krzesinski, Jean-Marie ;
Lautrette, Alexandre ;
Mariat, Christophe .
BMC NEPHROLOGY, 2014, 15
[9]   Proteomic Identification of Early Biomarkers of Acute Kidney Injury After Cardiac Surgery in Children [J].
Devarajan, Prasad ;
Krawczeski, Catherine D. ;
Nguyen, Mai T. ;
Kathman, Thelma ;
Wang, Zhu ;
Parikh, Chirag R. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2010, 56 (04) :632-642
[10]   FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury [J].
Dihazi, Hassan ;
Koziolek, Michael J. ;
Datta, Rabi R. ;
Wallbach, Manuel ;
Jung, Klaus ;
Heise, Daniel ;
Dihazi, Gry H. ;
Markovic, Ivana ;
Asif, Abdul R. ;
Mueller, Gerhard A. .
BLOOD PURIFICATION, 2016, 42 (03) :202-213