Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium

被引：16

作者：

Rouquet, Guy ^{[1
]}

Blakemore, David C. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Pfizer Worldwide Res & Dev, Neusentis Chem, Cambridge CB21 6GS, England

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 64期

关键词：

DIRECTED ORTHO-METALATION; DRUG DISCOVERY; ASYMMETRIC-SYNTHESIS; DERIVATIVES; STRATEGIES; DESIGN; FUNCTIONALIZATION; POLYMERIZATION; LITHIUM;

D O I：

10.1039/c4cc03766a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first regioselective ortho-lithiation at the 4-position of simple pyridine derivatives containing a 3-oxetane unit has been achieved using n-butyllithium as base. Electrophilic quenching of the resulting lithio species provides a rapid access to a broad range of new functionalized pyridine oxetane building blocks.

引用

页码：8908 / 8911

页数：4

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