Antiproliferative action of aqueous extracts of Hymenaea stigonocarpa Mart. (Fabaceae) on the cell cycle of Allium cepa L.

被引：19

作者：

Lacerda, Lourran P. ^{[1
]}

Malaquias, Geiz ^{[1
]}

Peron, Ana Paula ^{[1
]}

机构：

[1] UFPI, Nucl Pesquisa Aplicada Saude & Meio Ambiente, Lab Citogenet Vegetal & Anim, BR-64600000 Picos, PI, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2014年 / 86卷 / 03期

关键词：

Allium cepa; cellular division; cells in prophase; medicinal plant;

D O I：

10.1590/0001-3765201420130163

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study we evaluated the action of crude aqueous extracts obtained from rhytidome of Hymenaea stigonocarpa (jatoba-do-cerrado) on Allium cepa meristematic root cells in three concentrations: 0.082, 0.164, 0.328g/mL, at exposure times of 24 and 48 h. The slides were prepared by the crushing technique, and cells analyzed throughout the cell cycle, totaling 5000 for each control group and concentration. It was found that all three concentrations, including the lowest which is considered ideal for use, in all exposure times, had significant antiproliferative action on the cell cycle of this test system. For cells under division, we observed a high number of cells in prophase. Therefore, under the conditions studied H. stigonocarpa indicated to be cytotoxic.

引用

页码：1147 / 1150

页数：4

共 10 条

[1] Isolation and absolute configuration of ent-halimane diterpenoids from Hymenaea courbaril from the suriname rain forest [J].