Progenitor "Mycobacterium canettii" Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

被引：54

作者：

Blouin, Yann ^{[1
,2
]}

Cazajous, Geraldine

Dehan, Celine

Soler, Charles ^{[3
]}

Vong, Rithy ^{[3
]}

Hassan, Mohamed Osman

Hauck, Yolande ^{[1
,2
]}

Boulais, Christian

Andriamanantena, Dina ^{[4
]}

Martinaud, Christophe ^{[3
]}

Martin, Emilie ^{[5
]}

Pourcel, Christine ^{[1
,2
]}

Vergnaud, Gilles ^{[1
,2
,6
]}

机构：

[1] Univ Paris 11, F-91405 Orsay, France

[2] CNRS, F-91405 Orsay, France

[3] Hop Instruct Armees Percy, Clamart, France

[4] Hop Instruct Armees Begin, St Mande, France

[5] Ctr Hosp Lyon Sud, Lyon, France

[6] Inst Rech Biomed Armees, Bretigny Sur Orge, France

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 01期

关键词：

COMPLEX; EVOLUTION; ORIGIN;

D O I：

10.3201/eid2001.130652

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

"Mycobacterium canettii" an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the approximate to 70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.

引用

页码：21 / 28

页数：8

共 24 条

[11]

Gie R P, 2004, Paediatr Respir Rev, V5 Suppl A, pS147, DOI 10.1016/S1526-0542(04)90028-0

[12] Distributive Conjugal Transfer in Mycobacteria Generates Progeny with Meiotic-Like Genome-Wide Mosaicism, Allowing Mapping of a Mating Identity Locus [J].