Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes

被引：50
作者：
Kang, Hahk-Soo [1 ]
Brady, Sean F. [1 ]
机构：
[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Genet Encoded Small Mol, New York, NY 10065 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 42期
关键词：
anthracyclines; antitumor agents; MDR; metagenomics; natural products; II POLYKETIDE SYNTHASES; ANTHRACYCLINE ANALOGS; MICROBIAL DIVERSITY; ANTITUMOR-ACTIVITY; GENE-CLUSTER; DNA RECOVERY; BIOSYNTHESIS; MULTIDRUG; RESISTANCE; DISCOVERY;
D O I：
10.1002/anie.201305109
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycina A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：11063 / 11067
页数：5
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