Radiotherapy and checkpoint inhibitors: a winning new combination?

被引：84
作者：
Ko, Eric C. [1 ]
Formenti, Silvia C. [1 ]
机构：
[1] Weill Cornell Med, Dept Radiat Oncol, 525 East 68th St,N-046,Box 169, New York, NY 10065 USA
来源：
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2018年 / 10卷
关键词：
Radiotherapy; immunotherapy; immune checkpoint blockade; checkpoint inhibitors; CTLA-4; PD-1; PD-L1; metastatic disease; abscopal effect; stereotactic body radiation therapy; CELL LUNG-CANCER; TREATMENT-RELATED LYMPHOPENIA; LOCAL RADIATION-THERAPY; METASTATIC MELANOMA; ABLATIVE RADIATION; BRAIN METASTASES; PD-1; BLOCKADE; T-CELLS; IPILIMUMAB; NIVOLUMAB;
D O I：
10.1177/1758835918768240
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune checkpoint blockade has recently emerged as an important therapeutic approach to the management of malignancies across multiple disease settings. Concomitantly, there has been an increasing appreciation for the role of radiotherapy in eliciting and promoting tumor-directed immune responses. In this review, we discuss the clinical evidence to date on combinations of radiotherapy with immune checkpoint inhibitors, both from the standpoint of safety and efficacy. We highlight important but yet-unanswered questions for this combination approach, as well as their implications for future prospective studies.
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页码：1 / 11
页数：11
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