The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice

被引：1
作者：
Zhang, Minxia [1 ,2 ,3 ]
Zhao, Jiaqi [4 ]
Deng, Jianjun [1 ,2 ,3 ]
Duan, Zhiguang [1 ,2 ,3 ]
Zhu, Chenhui [1 ,2 ,3 ]
Fan, Daidi [1 ,2 ,3 ]
机构：
[1] Northwest Univ, Sch Chem Engn, Shaanxi Key Lab Degradable Biomed Mat, Xian 710069, Shaanxi, Peoples R China
[2] Northwest Univ, Sch Chem Engn, Shaanxi R&D Ctr Biomat & Fermentat Engn, Xian 710069, Shaanxi, Peoples R China
[3] Northwest Univ, Biotech & Biomed Res Inst, 229 North Taibai Rd, Xian 710069, Shaanxi, Peoples R China
[4] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
FOOD & FUNCTION | 2019年 / 10卷 / 07期
基金：
中国国家自然科学基金;
关键词：
INSULIN-RESISTANCE; GUT MICROBIOTA; EXPRESSION; ACTIVATION; OBESITY; PERMEABILITY; DIET;
D O I：
10.1039/c9fo00242a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protopanaxatriol saponin (PPT) has excellent anti-cancer, anti-diabetes, and anti-anemia effects, but its effect on intestinal bacteria has rarely been studied. In this study, we investigated whether PPT has the ability to improve intestinal health in antibiotic-treated mice. Model mice were constructed using a broad-spectrum antibiotic, cephalosporin. The composition of the gut microbiota and relative concentration of short-chain fatty acids (SCFAs), short-chain fatty acid receptor proteins (GPR41, GPR43 and GPR109A), tight junction components (ZO-1 and occludin) and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1 beta, IL-22 and IFN-gamma) were determined. The results showed that PPT improved the composition of the gut microbiota, increased the concentration of SCFAs as well as receptor proteins and tight junction proteins, and decreased the pro-inflammatory cytokines. These findings indicate that PPT has a protective effect on intestinal microbes and enhances the integrity of the intestinal barrier as well as alleviates colonic inflammation in antibiotic-treated mice.
引用
收藏
页码：4124 / 4133
页数：10
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