Synthesis and base-pairing properties of C-nucleotides having 1-substituted 1H-1,2,3-triazoles

被引：31

作者：

Nakahara, Motoi ^{[1
]}

Kuboyama, Takeshi ^{[1
]}

Izawa, Akihiro ^{[1
]}

Hari, Yoshiyuki ^{[1
]}

Imanishi, Takeshi ^{[1
]}

Obika, Satoshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 12期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

Click chemistry; Nucleobase analogues; Oligonucleotides; Post-elongation modification method; Triazoles; 2'; 4'-BRIDGED NUCLEIC-ACID; MOTIF TRIPLEX FORMATION; CLICK CHEMISTRY; PYRIMIDINE MOTIF; TERMINAL ALKYNES; RECOGNITION; OLIGONUCLEOTIDES; INTERRUPTION; NUCLEOBASE; NUCLEOSIDES;

D O I：

10.1016/j.bmcl.2009.04.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligonucleotides including C-nucleotides having 1-substitued 1H-1,2,3-triazoles as artificial nucleobases were conveniently synthesized by the post-elongation modification method using the copper(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction. The base-pairing properties of the triazole nucleobase analogs in forming duplexes with oligonucleotides were investigated by the T-m experiments. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3316 / 3319

页数：4

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