Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives

被引：69

作者：

Jiang, Zhengdong ^{[1
]}

Liang, Gang ^{[2
]}

Xiao, Ying ^{[1
]}

Qin, Tao ^{[1
]}

Chen, Xin ^{[1
]}

Wu, Erxi ^{[3
,4
,5
,6
,7
]}

Ma, Qingyong ^{[1
]}

Wang, Zheng ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China

[2] Shaanxi Nucl Ind, Dept Hepatobiliary Surg, Hosp 215, Xianyang, Shaanxi, Peoples R China

[3] Baylor Scott & White Hlth, Neurosci Inst, Dept Neurosurg, Temple, TX USA

[4] Baylor Scott & White Hlth, Neurosci Inst, Temple, TX USA

[5] Texas A&M Univ, Dept Surg, Hlth Sci Ctr, Coll Med, College Stn, TX 77843 USA

[6] Texas A&M Univ, Dept Pharmaceut Sci, Coll Pharm, College Stn, TX 77843 USA

[7] Univ Texas Austin, LIVESTRONG Canc Inst, Dell Med Sch, Austin, TX 78712 USA

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2019年 / 11卷

基金：

中国国家自然科学基金;

关键词：

migration; proliferation; SLIT; ROBO pathway; tumor; tumor microenvironment; FREQUENT EPIGENETIC INACTIVATION; SLIT-ROBO; CELL-MIGRATION; AXON GUIDANCE; EXPRESSION PATTERNS; VERTEBRATE SLIT; IN-VIVO; ROUNDABOUT; CANCER; PROTEIN;

D O I：

10.1177/1758835919855238

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The SLITs (SLIT1, SLIT2, and SLIT3) are a family of secreted proteins that mediate positional interactions between cells and their environment during development by signaling through ROBO receptors (ROBO1, ROBO2, ROBO3, and ROBO4). The SLIT/ROBO signaling pathway has been shown to participate in axonal repulsion, axon guidance, and neuronal migration in the nervous system and the formation of the vascular system. However, the role of the SLIT/ROBO pathway has not been thoroughly clarified in tumor development. The SLIT/ROBO pathway can produce both beneficial and detrimental effects in the growth of malignant cells. It has been confirmed that SLIT/ROBO play contradictory roles in tumorigenesis. Here, we discuss the tumor promotion and tumor suppression roles of the SLIT/ROBO pathway in tumor growth, angiogenesis, migration, and the tumor microenvironment. Understanding these roles will help us develop more effective cancer therapies.

引用

页数：14

共 100 条

[1] miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway [J].

Alajez, Nehad M. ;

Lenarduzzi, Michelle ;

Ito, Emma ;

Hui, Angela B. Y. ;

Shi, Wei ;

Bruce, Jeff ;

Yue, Shijun ;

Huang, Shao H. ;

Xu, Wei ;

Waldron, John ;

O'Sullivan, Brian ;

Liu, Fei-Fei .

CANCER RESEARCH, 2011, 71 (06) :2381-2391

[2] Quantification of SLIT-ROBO transcripts in hepatocellular carcinoma reveals two groups of genes with coordinate expression [J].

Avci, Mehmet Ender ;

Konu, Ozlen ;

Yagci, Tamer .

BMC CANCER, 2008, 8 (1)

[3] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[4] A Roundabout Way to Cancer [J].

Ballard, Mimmi S. ;

Hinck, Lindsay .

GUIDANCE MOLECULES IN CANCER AND TUMOR ANGIOGENESIS, 2012, 114 :187-235

[5] Repulsive axon guidance: Abelson and enabled play opposing roles downstream of the roundabout receptor [J].

Bashaw, GJ ;

Kidd, T ;

Murray, D ;

Pawson, T ;

Goodman, CS .

CELL, 2000, 101 (07) :703-715

[6] Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line [J].

Bauer, Karin ;

Dowejko, Albert ;

Bosserhoff, A-K. ;

Reichert, T. E. ;

Bauer, Richard .

CARCINOGENESIS, 2011, 32 (06) :935-943

[7] roundabout4 is essential for angiogenesis in vivo [J].

Bedell, VM ;

Yeo, SY ;

Park, KW ;

Chung, J ;

Seth, P ;

Shivalingappa, V ;

Zhao, JH ;

Obara, T ;

Sukhatme, VP ;

Drummond, IA ;

Li, DY ;

Ramchandran, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (18) :6373-6378

[8] Frequent alterations of SLIT2-ROBO1-CDC42 signalling pathway in breast cancer: clinicopathological correlation [J].

Bhattacharya, Rittwika ;

Mukherjee, Nupur ;

Dasgupta, Hemantika ;

Islam, Md. Saimul ;

Alam, Neyaz ;

Roy, Anup ;

Das, Priyobrata ;

Roychoudhury, Susanta ;

Panda, Chinmay Kumar .

JOURNAL OF GENETICS, 2016, 95 (03) :551-563

[9] Targeting the Hepatocyte Growth Factor-cMET Axis in Cancer Therapy [J].

Blumenschein, George R., Jr. ;

Mills, Gordon B. ;

Gonzalez-Angulo, Ana M. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (26) :3287-3296

[10] Slit proteins bind robe receptors and have an evolutionarily conserved role in repulsive axon guidance [J].

Brose, K ;

Bland, KS ;

Wang, KH ;

Arnott, D ;

Henzel, W ;

Goodman, CS ;

Tessier-Lavigne, M ;

Kidd, T .

CELL, 1999, 96 (06) :795-806

← 1 2 3 4 5 6 7 8 9 10 →