Scuteflorins A and B, Dihydropyranocoumarins from Scutellaria lateriflora

被引：25

作者：

Li, Jing ^{[1
]}

Ding, Yuanqing ^{[2
]}

Li, Xing-Cong ^{[2
]}

Ferreira, Daneel ^{[1
,2
]}

Khan, Shabana ^{[2
]}

Smillie, Troy ^{[2
]}

Khan, Ikhlas A. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

NEPALESE CRUDE DRUGS; NEOCLERODANE-TYPE DITERPENOIDS; ELECTRONIC CIRCULAR-DICHROISM; FLAVONOID CONSTITUENTS; BAICALENSIS GEORGI; DISCOLOR COLEBR; THEORETICAL CALCULATION; INSECT ANTIFEEDANTS; HERBAL REMEDIES; WATER EXTRACTS;

D O I：

10.1021/np900068t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new dihydropyranocoumarins, scuteflorins A (1) and B (2), together with the known compounds decursin (3), chrysin (4), oroxylin A (5), wogonin (6), 5,7-dihydroxy-8,2'-dimethoxyflavone, dihydrochrysin, dihydrooroxylin A, lupenol, scutellaric acid, pomolic acid, ursolic acid, beta-sitosterol, daucosterol, and palmitic acid, were isolated from the aerial parts of Scutellaria lateriflora, commonly used as a dietary supplement. The structures of 1 and 2 were established by means of 1D and 2D NMR spectra as well as HRMS data. The absolute configuration of coumarins 1 and 2 was determined by comparison of experimental and theoretical calculated CD spectra. The cytotoxicity and antioxidant effects of the methanol extract of this plant and some of the constituent flavonoids were evaluated in vitro.

引用

页码：983 / 987

页数：5

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