Spiroisoxazoline synthesis via intramolecular cyclization/methylation

被引：9
作者：
Xu, Jianping [1 ]
Wang, Jun [1 ]
Ellis, Erick D. [1 ]
Hamme, Ashton T., II [1 ]
机构：
[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA
来源：
SYNTHESIS-STUTTGART | 2006年 / 22卷 / 22期
关键词：
spiro compounds; regioselectivity; cycloadditions; ring closure; heterocycles;
D O I：
10.1055/s-2006-950302
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of regioisomeric spiroisoxazolines was achieved through an intramolecular cyclization/methylation reaction of a functionalized 5,5 -disubstituted isoxazoline in one reaction vessel. The 5,5-isoxazoline was constructed through a 1,3-dipolar cycloaddition reaction of an aromatic nitrile oxide and a geminal disubstituted alkene.
引用
收藏
页码：3815 / 3818
页数：4
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