The Domino Chromone Annulation and a Transient Halogenation-Mediated C-H Alkenylation toward 3-Vinyl Chromones

被引：91

作者：

Fu, Leiqing ^{[1
,2
]}

Xu, Zhongrong ^{[1
]}

Wan, Jie-Ping ^{[1
]}

Liu, Yunyun ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

[2] Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Jiangxi, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 24期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; TETRASUBSTITUTED OLEFINS; EFFICIENT SYNTHESIS; GENERAL-APPROACH; BOND ACTIVATION; FUNCTIONALIZATION; ARYLATION; ALKENES; DERIVATIVES; ENAMINONES;

D O I：

10.1021/acs.orglett.0c03548

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reported in this paper is a step economical method toward the general synthesis of 3-vinyl chromones via the reactions between readily available o-hydroxyphenyl enaminones and various alkenes. The domino C-H alkenylation and chromone annulation of the enaminones are involved, which enables the synthesis of 3-vinyl chromone products using both terminal and internal alkenes via a key process of transient C-H halogenation.

引用

页码：9518 / 9523

页数：6

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