RNase L: Its biological roles and regulation

被引：83

作者：

Liang, Shu-Ling

Quirk, David

Zhou, Aimin

机构：

[1] Cleveland State Univ, Dept Chem, Clin Chem Program, Cleveland, OH 44115 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD USA

来源：

IUBMB LIFE | 2006年 / 58卷 / 09期

关键词：

interferon; RNase L; antivirus; apoptosis; prostate cancer;

D O I：

10.1080/15216540600838232

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.

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收藏

页码：508 / 514

页数：7

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