Androgen actions in the ovary: balance is key

被引：107

作者：

Prizant, Hen ^{[1
]}

Gleicher, Norbert ^{[2
]}

Sen, Aritro ^{[1
,2
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Med, Div Endocrinol & Metab, Rochester, NY 14642 USA

[2] Ctr Human Reprod, New York, NY 10021 USA

来源：

JOURNAL OF ENDOCRINOLOGY | 2014年 / 222卷 / 03期

关键词：

androgen; androgen receptor; female reproduction; ovary; FOLLICLE-STIMULATING-HORMONE; RECEPTOR MESSENGER-RNA; DIFFERENTIATION FACTOR 9; RAT GRANULOSA-CELLS; GROWTH-FACTOR-I; POOR RESPONDERS; PRIMATE OVARY; FEMALE MICE; CYTOCHROME-P450; AROMATASE; ANTRAL FOLLICLES;

D O I：

10.1530/JOE-14-0296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For many decades, elevated androgens in women have been associated with poor reproductive health. However, recent studies have shown that androgens play a crucial role in women's fertility. The following review provides an overall perspective about how androgens and androgen receptor-mediated actions regulate normal follicular development, as well as discuss emerging concepts, latest perceptions, and controversies regarding androgen actions and signaling in the ovary.

引用

页码：R141 / R151

页数：11

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