Steroids for Acute Respiratory Distress Syndrome?

被引：36
作者：
Hough, Catherine L. [1 ]
机构：
[1] Univ Washington, Div Pulm & Crit Care Med, Harborview Med Ctr, Seattle, WA 98104 USA
来源：
CLINICS IN CHEST MEDICINE | 2014年 / 35卷 / 04期
关键词：
ARDS; Corticosteroids; Prevention; Treatment; Outcomes; INTENSIVE-CARE-UNIT; ACUTE LUNG INJURY; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PNEUMOCYSTIS-CARINII-PNEUMONIA; HIGH-DOSE METHYLPREDNISOLONE; POSTTRAUMATIC-STRESS; ADJUNCTIVE THERAPY; PULMONARY FIBROSIS; CRITICAL-APPRAISAL; CLINICAL-TRIAL;
D O I：
10.1016/j.ccm.2014.08.014
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The development and severity of acute respiratory distress syndrome (ARDS) are closely related to dysregulated inflammation, and the duration of ARDS and eventual outcomes are related to persistent inflammation and abnormal fibroproliferation. Corticosteroids are potent modulators of inflammation and inhibitors of fibrosis that have been used since the first description of ARDS in attempts to improve outcomes. There is no evidence that corticosteroids prevent the development of ARDS among patients at risk. High-dose and short-course treatment with steroids does not improve the outcomes of patients with ARDS. Additional studies are needed to recommend treatment with steroids for ARDS.
引用
收藏
页码：781 / +
页数：16
相关论文
共 81 条
  • [1] Do glucocorticoids decrease mortality in acute respiratory distress syndrome? A meta-analysis
    Agarwal, Ritesh
    Nath, Alok
    Aggarwal, Ashutosh N.
    Gupta, Dheeraj
    [J]. RESPIROLOGY, 2007, 12 (04) : 585 - 590
  • [2] Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome
    Annane, D
    Sébille, V
    Bellissant, E
    [J]. CRITICAL CARE MEDICINE, 2006, 34 (01) : 22 - 30
  • [3] Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Annane, D
    Sébille, V
    Charpentier, C
    Bollaert, PE
    François, B
    Korach, JM
    Capellier, G
    Cohen, Y
    Azoulay, E
    Troché, G
    Chaumet-Riffaut, P
    Bellissant, E
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (07): : 862 - 871
  • [4] Argov Zohar, 2014, Handb Clin Neurol, V121, P1673, DOI 10.1016/B978-0-7020-4088-7.00108-5
  • [5] ASHBAUGH DG, 1967, LANCET, V2, P319
  • [6] ASHBAUGH DG, 1985, ARCH SURG-CHICAGO, V120, P530
  • [7] Dexamethasone in patients with acute lung injury from acute monocytic leukaemia
    Azoulay, E.
    Canet, E.
    Raffoux, E.
    Lengline, E.
    Lemiale, V.
    Vincent, F.
    de Labarthe, A.
    Seguin, A.
    Boissel, N.
    Dombret, H.
    Schlemmer, B.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2012, 39 (03) : 648 - 653
  • [8] Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle
    Balas, Michele C.
    Vasilevskis, Eduard E.
    Olsen, Keith M.
    Schmid, Kendra K.
    Shostrom, Valerie
    Cohen, Marlene Z.
    Peitz, Gregory
    Gannon, David E.
    Sisson, Joseph
    Sullivan, James
    Stothert, Joseph C.
    Lazure, Julie
    Nuss, Suzanne L.
    Jawa, Randeep S.
    Freihaut, Frank
    Ely, E. Wesley
    Burke, William J.
    [J]. CRITICAL CARE MEDICINE, 2014, 42 (05) : 1024 - 1036
  • [9] Biomarkers in Acute Lung Injury-Marking Forward Progress
    Barnett, Nicolas
    Ware, Lorraine B.
    [J]. CRITICAL CARE CLINICS, 2011, 27 (03) : 661 - +
  • [10] HIGH-DOSE CORTICOSTEROIDS IN PATIENTS WITH THE ADULT RESPIRATORY-DISTRESS SYNDROME
    BERNARD, GR
    LUCE, JM
    SPRUNG, CL
    RINALDO, JE
    TATE, RM
    SIBBALD, WJ
    KARIMAN, K
    HIGGINS, S
    BRADLEY, R
    METZ, CA
    HARRIS, TR
    BRIGHAM, KL
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (25) : 1565 - 1570
123456789